Morphological Changes of Kidney Tissue When Using Glutathione at Rhabdomyolytic Acute Kidney Injury
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چکیده
Morphological study of rats kidneys after the simulation of rhabdomyolytic acute kidney injury by the single injection of 50% glycerol revealed the morphological changes in the renal cortex and medulla, which were manifested by the luminal obstruction of the cortical and medullary tubules with myoglobin casts, epithelial dystrophy and signs of coagulative necrosis. Use of glutathione improved the renal histology significantly, which was confirmed by restriction of dystrophy and necrotic processes, indicating its nephroprotective activity.
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